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KMID : 0043320100330060831
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Archives of Pharmacal Research
2010 Volume.33 No. 6 p.831 ~ p.842
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Synthesis and Preliminary Antibacterial Evaluation of 2-Butyl Succinate- based Hydroxamate Derivatives Containing Isoxazole Rings
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Wang Jian-Wu
Zhang Da-Tong
Jia Jiong
Meng Li-Juan
Xu Wei-Ren
Tang Li-Da
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Abstract
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Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.
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KEYWORD
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2-Butyl succinate-based hydroxamate derivatives, Isoxazole, Synthesis, Antibacterial activity
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